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Epitalon

Longevity & mitochondrial

Also known as Epithalon, Ala-Glu-Asp-Gly

A four-amino-acid peptide studied in Russia for telomerase activation and ageing.

Read this first
Two things worth knowing. There are zero registered clinical trials of this compound, the only two published human studies used 5 micrograms per eye and 0.5 mg sublingually, so the community injection dose of 5 to 10 mg is roughly twenty times higher than any published human dose, by a different route. And the entire selling proposition, telomerase activation, is also a hallmark of cellular immortalisation; the oncological implication of chronic systemic telomerase induction has never been assessed in people.

How it works

A synthetic tetrapeptide based on epithalamin, a pineal extract. Reported to activate telomerase and normalise melatonin rhythm. The supporting work is almost entirely from a single Russian research group.

Subcutaneous

In the body

No plasma curve is shown for this compound.

No pharmacokinetic data was located in any species.

Doses

5 mg, 10 mgonce daily for a 10 to 20 day courseCommunity practice

Community convention, usually run as short courses once or twice a year rather than continuously.

Vial sizes

10 mg20 mg50 mg

Commonly treated as good for 28 days refrigerated once reconstituted.

Side effects

  • No systematic safety data outside the originating research group.

Cautions

  • No established contraindications.

Status

Not approved outside Russia. An FDA advisory committee voted 7 to 5 in favour of the 503A compounding list in July 2026. That vote is non-binding.

Sources

Reference information for personal record-keeping. Not medical advice, and not a recommendation to use any of these compounds.