MOTS-c
Longevity & mitochondrialAlso known as mitochondrial ORF of the twelve S rRNA type-c
A 16-amino-acid peptide encoded in mitochondrial DNA.
How it works
A mitochondrial-derived peptide that activates AMPK and influences the folate, methionine cycle, shifting cells toward glucose utilisation. Studied for insulin sensitivity and exercise capacity.
In the body
No plasma curve is shown for this compound.
No human pharmacokinetic data was located.
Doses
Community convention. No human trial dosing exists.
Vial sizes
Commonly treated as good for 28 days refrigerated once reconstituted.
Side effects
- No human safety data exists.
Cautions
- No established contraindications, because no human study has been done.
Status
Not approved. An FDA advisory committee voted 7 to 5 in favour of adding it to the 503A compounding list in July 2026, nominated for obesity and osteoporosis. That vote is non-binding.
Reference information for personal record-keeping. Not medical advice, and not a recommendation to use any of these compounds.