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Selank

Cognitive

Also known as TP-7, Selanx

An anxiolytic peptide developed in Russia, and the usual companion to Semax.

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The evidence is a small Russian literature that has not been replicated elsewhere. Dose ranges come from those studies rather than from anything independent.

How it works

A synthetic analogue of the immunomodulatory peptide tuftsin, stabilised with the same proline-glycine-proline tail that Semax carries. Reported to act on GABAergic and serotonergic signalling and to raise BDNF, without the sedation or dependence associated with benzodiazepines.

IntranasalSubcutaneous

In the body

No plasma curve is shown for this compound.

Not established in humans. The parent peptide is degraded in plasma within minutes, and intranasal absorption rather than clearance is likely to govern how long anything is present, but no study has measured it, so no curve is drawn.

Doses

250 mcg, 900 mcgdaily, usually split between nostrilsEarly human data

The range used in Russian clinical work on generalised anxiety disorder. Those studies are small, largely unreplicated outside Russia, and mostly unavailable in English.

Vial sizes

5 mg10 mg

Commonly treated as good for 28 days refrigerated once reconstituted.

Side effects

  • Nasal irritation with the intranasal form
  • Fatigue or flatness in some users
  • The safety record rests on small studies from a single country

Cautions

  • Pregnancy
  • No meaningful interaction data exists, so caution alongside psychiatric medication

Status

Registered as a medicine in Russia; not approved anywhere in the EU or the United States, where it is sold as a research chemical.

Sources

Reference information for personal record-keeping. Not medical advice, and not a recommendation to use any of these compounds.